Beilstein J. Nanotechnol.2017,8, 1307–1317, doi:10.3762/bjnano.8.132
investigates the chemosensitizing potential of CNFs and CNTs to the conventional chemotherapeutics docetaxel (DTX) and mitomycinC (MMC), which have different molecular structures and mechanisms of action than platinum-based chemotherapeutics. DU-145 PCa cells were treated with DTX and MMC alone or in
. Co-administration of chemotherapeutics with carbon nanomaterials could result in a reduction of the chemotherapeutic dosage and thus limit systemic side effects.
Keywords: carbon nanomaterials; chemosensitization; docetaxel; mitomycinC; prostate cancer cells; Introduction
According to the global
mitomycinC (MMC), regarding their cytotoxic effects when applied in combination with carbon nanomaterials. DTX is a cytostatic taxane approved for the palliative treatment of castration-resistant PCa [29]. It promotes microtubule stabilization, acts anti-mitotic and initiates apoptosis resulting in cell
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Figure 1:
Relative cellular viability of DU-145 cells treated with (a) 1.5 ng/mL DTX or (b) 0.3 µg/mL MMC in ...